SAG stands for Super antigen. Super antigen are a body of antigens( an antigen is a substance that prompts the production of antibodies it can also cause an immune response) which result in non – specific activation of T – cells which lead to what is called polyclonal T cell activation and colossal cytokine release. Pathogenic microbes can produce SAGs which act as a type of security system adjacent to the immune system. SAGs have the capability and capacity to stimulate as much as 20% of the body’s T-cell when compared to regular antigen – induced T – cell response. These regular antigen – induced t – cells produce a response of .001 – .0001%. Anti – CD 28 antibodies and Anti – CD3 have been discovered to be highly powerful super antigens, they are able to stimulate in excess of 100% of T cells.
Activated T cells by large stimulate an enormous immune response which is not unique to any particular epitope on the SAG. The adaptive immune system is able to target antigens...










